This essay surveys the evolution of historical scholarship on epidemic diseases in the Mediterranean/Islamicate world with a particular focus on plague. Temporally, it covers the scholarship on plague epidemics during the last 1,500 years, surveyed in three major pandemics: first, second, and third pandemics of plague. Geographically, it addresses the Mediterranean basin and its hinterland, including the Middle East and North Africa (MENA), the Anatolian peninsula, the Balkans, and occasionally drawing on adjacent areas such as the Black Sea region and (...) the Persian plateau. It outlines major trends and turning points in the modern historiography; reviews prevailing paradigms, contested issues, and emergent consensuses; and identifies methodologies, sources, and approaches. Whenever possible, it highlights contributions from paleogenetic and other scientific studies, with special reference to the diversity of opinions, actors, and materials in this highly controversial but vigorous field of study. The major goal of this essay is to reunite the divided historiographies of the Mediterranean world, which are typically studied separately in the case of Europe and the Islamicate world, with a view to underscoring their shared epidemiological experiences. (shrink)